The Lake Amatitlán with its surrounding valleys, mountains and volcanoes has a unique landscape, which is used by many people as recreation area.
There are archeological remains dating back to the year 2000 B.C.. The town of Amatitlan was founded in 1536 and developed quickly. Since the colonial time, the lake is a centre of fishery. Its catchment area was the most important site of cochineal production (E 120), which was the main product for export when industrial chemicals had not yet replaced the natural dye. The lake water is also used for domestic use, irrigation and industrial activities. In 1800, the average depth of the lake measured 33 m, in the year 1996 the depth was only 18 m.